
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

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The investigation into the murder of a management consultant whose remains were partially eaten by bobcats leads to a marriage retreat site; Cam's identity is stolen; Sweets decides to take a leave of absence.

The team investigates when a gang member's remains are found in a burnt-out car; when Sweets learns that one of the boys from the center where he volunteers is a gang member's son, he decides to help.

The team devises a plan to use a donated cadaver to draw out Pelant; Sweets returns to work and believes Agent Flynn isn't who he seems.

The team investigates the murder of a high school principal who was dying of cancer; Brennan and Booth plan their wedding; a virtual profiling system threatens Sweets' job.