After uniting with the Witchblade, an ancient weapon of ecstasy and pain that penetrates the body and mind, Masane's fate was altered. Masane is hunted by the NSWF and is forced to work for the Doji Group, putting her in a battle with her soul.

Masane and her allies prepare for battle; as three twisted Cloneblades move to take the Witchblade by force, thousands of I-Weapons approach to violently complicate matters.

The final battle between the Witchblade and the Cloneblades erupts; consumed with madness, Maria leads her Sisters into a clash with Masane; high atop Tokyo Tower, everyone faces their destiny.

After arriving in Tokyo, Masane becomes unhinged when the Child Welfare Ministry spirits away Rihoko; in the chaos, the Witchblade gets unleashed.

Masane, reborn a furious force of nature, gets conscripted into service by the Doji Group; while the reality of Masane's new life sets in, her daughter Rihoko wanders Tokyo alone.