
After a brain injury erases the last eight years of Dr. Amy Larsen's life, she must navigate an unfamiliar world where she has no recollection of patients she's treated, colleagues she's crossed, the soulmate she divorced, the man she now loves or the tragedy that caused her to push everyone away. She can rely only on her estranged 17-year-old daughter, whom she remembers as a 9-year-old, and a handful of devoted friends, as she struggles to continue practicing medicine, despite having lost nearly a decade of knowledge and experience.
Amy and Jake are paired together on a bizarre case that lays bare the still-raw feelings surrounding their fractured relationship; Michael and Sonya are thrust into a family crisis while trying to save a young addict.
Amy and Ben go toe to toe when their cancer patient demands the impossible; Jake discovers a senior Westside surgeon has botched an operation, and he must decide whether to speak out and risk his tenuous new position in cardiology; Sonya grapples with the weight of life-changing news.