
Martin Best is a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin's blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he's all they've got. Although Martin can expertly address any medical ailment or mystery in this idiosyncratic town, he's really just desperate to be left the hell alone. Instead, he keeps getting dragged right smack into the middle of their personal chaos, feuds and fantasies. What the locals don't know is that Martin's terse demeanor masks a debilitating new phobia and deep-seated psychological issues that prevent him from experiencing true intimacy with anyone. But tenacity is the creed of everyone in their small village, and the people who live there may be exactly what the doctor ordered.

Port Wenn goes on lockdown when a patient with fleas sparks fears of a plague outbreak; Martin must deal with the town gossip when it revolves around him and Louisa; Aunt Sarah feels betrayed by Greg and George; Louisa has an epiphany.

Martin is skeptical when Port Wenn welcomes a friendly delegation from their sister city in Norway; Louisa visits a specialist who just happens to be Martin's ex; Greg believes that he is pooping little men; Mark exhibits troubling symptoms.