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Virginia at LouisvilleNCAAFThe No. 11 Cardinals (8-1, 5-1) try to hang on to second place in the ACC as they host the upset-minded Cavaliers (2-7, 1-4). Louisville won its last two games by a combined 57-3 score, and controls its own destiny in playing for the ACC title.
Louisville at MiamiNCAAFThe Hurricanes (6-4, 2-4 ACC) host the No. 10 Cardinals (9-1, 6-1). Louisville's lone loss came in its last road outing Oct. 14, while Miami earned back-to-back overtime wins in its most recent stretch at home. Miami toppled Louisville 47-34 in 2020.
Louisville vs Florida StateNCAAFThe No. 4 Seminoles (12-0) collide with the No. 14 Cardinals (10-2) in the ACC championship game. Florida State kept its College Football Playoff hopes alive with its 18th straight win, 24-15 over rival Florida. Louisville plays for its first title.
Notre Dame at LouisvilleNCAAFThe No. 10 Fighting Irish face another road test when they clash with the No. 25 Cardinals. Louisville is 5-0 for the first time since 2013 after edging NC State 13-10. Notre Dame came from behind to defeat then-No. 17 Duke 21-14 in Week 5.
Louisville at NC StateNCAAFThe Cardinals visit the Wolfpack. Louisville (4-0, 2-0 ACC) leads the all-time series with NC State (3-1, 1-0) by an 8-4 margin after a 25-10 decision in 2022. Cardinals receiver Jamari Thrash has turned 19 catches into 400 yards and five touchdowns.
Boston College at LouisvilleNCAAFThe undefeated Cardinals welcome the upset-minded Eagles to the Bluegrass State for an ACC affair. Louisville comes off a 21-14 victory over Indiana. Boston College had a chance to stun then-No. 3 Florida State, but came up short 31-29 in Week 3.