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Notre Dame at LouisvilleNCAAFThe No. 10 Fighting Irish face another road test when they clash with the No. 25 Cardinals. Louisville is 5-0 for the first time since 2013 after edging NC State 13-10. Notre Dame came from behind to defeat then-No. 17 Duke 21-14 in Week 5.
Virginia at LouisvilleNCAAFThe No. 11 Cardinals (8-1, 5-1) try to hang on to second place in the ACC as they host the upset-minded Cavaliers (2-7, 1-4). Louisville won its last two games by a combined 57-3 score, and controls its own destiny in playing for the ACC title.
Louisville at MiamiNCAAFThe Hurricanes (6-4, 2-4 ACC) host the No. 10 Cardinals (9-1, 6-1). Louisville's lone loss came in its last road outing Oct. 14, while Miami earned back-to-back overtime wins in its most recent stretch at home. Miami toppled Louisville 47-34 in 2020.