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Karen Read's defense tried to discredit the State's key witness. According to Jennifer McCabe, the defendant was the one who admitted that she hit her boyfriend, John O'Keefe, with her car. The Defense brought up the 911 call McCabe made that morning. Before McCabe took the stand, no one else had claimed that read and O'Keefe got into a fight before he died. This aligned with the State's allegation that the defendant killed him because their relationship became strained.

Jennifer McCabe told jurors that Karen Read's SUV had a cracked taillight. She was on the stand testifying about what happened when she and Karen Read got to the scene and eventually discovered John O'Keefe in the snow. Prosecutors believe the defendant used that car to hit him and then left him to die. During this long cross-examination, McCabe denied deleting text messages and phone logs in the days after O'Keefe's death.

The sparring between Karen Read's attorney and the prosecution's key witness was not over yet. Under cross-examination, Jennifer McCabe continued to deny that she and her family took part in a cover-up linked to the death of John O'Keefe. Jurors listened to what a key witness did in the days following John O'Keefe's death. The defense was trying to show that Jennifer McCabe's actions and statements to police were suspicious. But she denied that she was trying to cover anything up.

On the stand, Aileen Wuornos said she had no choice but to kill Richard Mallory, the first of seven victims; the confessed killer claimed she feared for her life after an attempted rape.

The lead investigator in the case was back on the stand; once investigators linked the murders of seven men in central Florida, multiple counties and even the FBI got involved in the manhunt.

The Defense began closing arguments telling jurors that Aileen Wuornos did not intentionally kill Richard Mallory; the Defense continued its strategy of having the jury focus on that one particular death, and not the other homicides.

During closing arguments, the State focused on the pattern of behavior that it said proved Aileen Wuornos operated as a serial killer.

A forensic psychiatrist hired by the defense team to examine the defendant testified that Jeffrey Dahmer tried to resist his sexual desires and urges but ultimately failed resulting in his serial killing spree.