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When Tom Wright, a senator with presidential aspirations, becomes ill, House examines him and finds that the symptoms point toward AIDS, a condition that would squash his career.

House and his team scramble to find the cause of kidney and brain dysfunction in a pregnant patient, leaving the woman and her husband to face a heartbreaking choice; Vogler continues his quest to have House fired.

A meningitis scare overwhelms the resources and staff of the hospital, but House singles out a 12-year-old patient whose symptoms are similar to but not quite right for the disease.

Gus and Shawn spend a weekend searching for a missing teen at a comic-book and sci-fi convention.

When Henry's former captain, suffering from early onset Alzheimer's, knows he has solved a crime but cannot remember it, he turns to Shawn for help.

Jared is ordered to serve as a small claims court judge; Jared goes head-to-head with his father in court on a case involving a rock star; Infeld's life coach is exposed as a fraud.

Dean Pelton hires an administrative consultant (Paget Brewster) to organize things at Greendale; Abed is pitted against Jeff, Annie and Britta.

Jeff and Frankie (Paget Brewster) ask an inventor (Keith David) for help extracting Dean Pelton from his pricey virtual reality world; Britta discovers an unsettling fact about her mother (Leslie Ann Warren) and father (Martin Mull).