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Marshall Lawson's (Steven Seagal) entire military strike force is eradicated in a vicious attack in Paris. With help from his chemist girlfriend, Tia (Lisa Lovbrand), Marshall learns that the murderer was on a new drug called CTX, which turns people into unstoppable killing machines. Now a government agent named Werner (Danny Webb) is trying to get Marshall out of the way so a nightclub owner and drug dealer (Adam Croasdell) can release CTX to the entire population of Paris.

When slacker teen Anton Tobias (Devon Sawa) has his right hand possessed by a demonic force, he finds that his life gets a lot more interesting. While Anton himself is an amiable guy, his hand proves to be an appendage of death, killing his two best buddies, Pnub (Elden Henson) and Mick (Seth Green), who return to life as wisecracking zombies. In addition to murdering those closest to him, Anton's evil hand significantly hinders his chances with lovely neighbor Molly (Jessica Alba).

Bill Johnson leads a group of scientists into the jungles of Borneo. They are searching for the mythical black orchid, which can supposedly grant eternal life. Unfortunately, massive anacondas have been feeding on the orchids for years. When their boat goes over a waterfall, the scientists land right in the middle of the snakes' home.

A mercenary-for-hire accepts a mission from a billionaire to capture a dangerous snake that could possibly help cure a terminal illness.

A genetically created Anaconda, cut in half, regenerates itself into two aggressive giant snakes, due to the Blood Orchid.

Feeling responsible for his father's death, which occurred during a climbing expedition, Peter Garrett (Chris O'Donnell) has quit the pursuit in favor of photography, while his sister, Annie (Robin Tunney), has become a top climber. After Annie is hired by wealthy businessman Elliot Vaughn (Bill Paxton) to lead a trek, inclement weather causes the crew to become trapped. Facing his fears, Peter assembles a rescue team, including experienced climber Montgomery Wick (Scott Glenn), to save them.

A death-row inmate (Paul Walker) searches for the truth after he mysteriously awakes in a psychiatric hospital.

The Rev. Moore is prosecuted for the wrongful death of a girl thought to be demonically possessed, because he administered the church-sanctioned exorcism that ultimately killed her. Prosecuting attorney Ethan Thomas contends that the young woman, Emily, suffered from schizophrenia and should have been medically diagnosed. Meanwhile, defense lawyer Erin Bruner argues that Emily's condition cannot be explained by science alone.