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A mercenary-for-hire accepts a mission from a billionaire to capture a dangerous snake that could possibly help cure a terminal illness.

A genetically created Anaconda, cut in half, regenerates itself into two aggressive giant snakes, due to the Blood Orchid.

Feeling responsible for his father's death, which occurred during a climbing expedition, Peter Garrett (Chris O'Donnell) has quit the pursuit in favor of photography, while his sister, Annie (Robin Tunney), has become a top climber. After Annie is hired by wealthy businessman Elliot Vaughn (Bill Paxton) to lead a trek, inclement weather causes the crew to become trapped. Facing his fears, Peter assembles a rescue team, including experienced climber Montgomery Wick (Scott Glenn), to save them.

A death-row inmate (Paul Walker) searches for the truth after he mysteriously awakes in a psychiatric hospital.

The Rev. Moore is prosecuted for the wrongful death of a girl thought to be demonically possessed, because he administered the church-sanctioned exorcism that ultimately killed her. Prosecuting attorney Ethan Thomas contends that the young woman, Emily, suffered from schizophrenia and should have been medically diagnosed. Meanwhile, defense lawyer Erin Bruner argues that Emily's condition cannot be explained by science alone.

Reporter Angela (Jennifer Carpenter) and her cameraman Scott (Steve Harris) are doing a story on night-shift firefighters for a reality-TV program. A late-night distress call takes them to a Los Angeles apartment building, where the police are investigating a report of horrific screams. The TV team and emergency workers find an old woman, who suddenly attacks with teeth bared. What's more, Angela and company find that the building has been sealed by CDC workers. Then the attacks really begin.

Far away from the site of a gruesome murder, a teenager named Jill Johnson (Camilla Belle) arrives at a luxurious home for a baby-sitting job. With the children fast asleep, she settles in for what she expects to be an ordinary evening. Soon, the ringing of a phone and the frightening words of a sadistic caller turn Jill's routine experience into a night of terror.

Strange things begin to occur as a tiny California coastal town prepares to commemorate its centenary. Inanimate objects spring eerily to life; Rev. Malone stumbles upon a dark secret about the town's founding; radio announcer Stevie witnesses a mystical fire; and hitchhiker Elizabeth discovers the mutilated corpse of a fisherman. Then a mysterious iridescent fog descends upon the village, and more people start to die.