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Tulane at Duke
NCAAFThe Tulane Green Wave meet the Duke Blue Devils at Wallace Wade Stadium in Durham. Tulane suffered a 41-10 loss to Ole Miss in December 2025, while Duke ended their 2025 season with a four-game win streak, including a 42-39 win against Arizona State.
Virginia Military Institute at Virginia Tech
NCAAFThe VMI Keydets meet the Virginia Tech Hokies at Lane Stadium in Blacksburg for an NCAA matchup. The Keydets finished their 2025 season with a brutal 1-11 record, while the Hokies concluded their season with a four-game losing streak.
24 Louisville at 9 Ole Miss
NCAAFOle Miss plays Louisville at Nissan Stadium for a Sunday prime-time Week 1 kickoff. Both programs look to establish early momentum in their season opener after finishing 13-2 and 9-4 respectively in their college football campaigns last year.
7 Miami at Stanford
NCAAFThe Stanford Cardinal host the Miami Hurricanes at Stanford Stadium for a Friday ACC opener. The Cardinal look to build on a 37-27 opening-week win against Hawaii, while visiting Miami aims to recover from a 27-21 national title game loss.
Florida A&M at 7 Miami
NCAAFMiami hosts Florida A&M at Hard Rock Stadium as both programs kick off Week 2 action. Miami counts on QB Darian Mensah after a dominant 45-6 win over Stanford, while visiting Florida A&M aims to bounce back from a 31-13 setback in their opening week.
17 SMU at Florida State
NCAAFFlorida State hosts SMU at Doak Campbell Stadium for a Labor Day ACC opener. SMU looks to start the season strong following a 24-19 Holiday Bowl win against the Wildcats in January, while Seminoles aim to build on their 17-34 win against the Aggies.
New Hampshire at Syracuse
NCAAFThe Syracuse Orange host the New Hampshire Wildcats at the JMA Wireless Dome for Week 1. Syracuse kicks off its 2026 campaign under the roof in its home arena, taking on an FCS postseason regular in New Hampshire for a regional game.
Villanova at 24 Louisville
NCAAFThe No. 24 Louisville Cardinals host the Villanova Wildcats at LN Federal Credit Union Stadium. Louisville features dual-threat quarterback Lincoln Kienholz, while Villanova relies on running back Isaiah Ragland in this non-conference game.
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25 Virginia Wise at Presbyterian
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Boston College at Cincinnati
NCAAFThe Bearcats host the Eagles at Nippert Stadium as both programs kick off Week 1. Cincinnati starts fresh after closing 2025 with a 35-13 Liberty Bowl loss against the Midshipmen, while Boston College looks to build on its 34-12 win over Syracuse.
Akron at Wake Forest
NCAAFThe Zips and the Demon Deacons meet for an interconference game at Allegacy Federal Credit Union Stadium. Akron won against Bowling Green 19-16 in their final game in 2025. Wake Forest defeated Mississippi State 43-29 in their last 2025 game.
UCLA at California
NCAAFThe UCLA Bruins face the California Golden Bears at California Memorial Stadium in Berkeley. The Bruins ended their 2025 season with a five-game losing streak, while the Golden Bears lost against the Rainbow Warriors 35-31 in December 2025.
7 Miami at Stanford
NCAAFThe Stanford Cardinal host the Miami Hurricanes at Stanford Stadium for a Friday ACC opener. The Cardinal look to build on a 37-27 opening-week win against Hawaii, while visiting Miami aims to recover from a 27-21 national title game loss.
Clemson at 8 LSU
NCAAFLSU plays host to Clemson at Tiger Stadium as both teams kick off the 2026 season. Both teams open the 2026 season seeking a marquee non-conference victory after completing their respective 7-6 campaigns in 2025 with bowl game defeats.
17 SMU at Florida State
NCAAFFlorida State hosts SMU at Doak Campbell Stadium for a Labor Day ACC opener. SMU looks to start the season strong following a 24-19 Holiday Bowl win against the Wildcats in January, while Seminoles aim to build on their 17-34 win against the Aggies.
24 Louisville at 9 Ole Miss
NCAAFOle Miss plays Louisville at Nissan Stadium for a Sunday prime-time Week 1 kickoff. Both programs look to establish early momentum in their season opener after finishing 13-2 and 9-4 respectively in their college football campaigns last year.