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11 Oklahoma at Michigan
NCAAFMichigan hosts No. 11 Oklahoma at Michigan Stadium in Week 2 play. Michigan relies on quarterback Bryce Underwood following his 2,428 passing yards, while visiting Oklahoma counters behind John Mateer, who threw for 2,885 yards and 14 touchdowns.
Iowa State at 21 Iowa
NCAAFThe Iowa State Cyclones take on the No. 21 Iowa Hawkeyes at Kinnick Stadium in Iowa City. Both teams enter 1-0. Iowa opened with a shutout over Northern Illinois, while Iowa State beat Southeast Missouri State, 38-10, in its opener.
Michigan State at Boston College
NCAAFThe Spartans visit the Eagles. Michigan State is off to its second 3-0 start in four years after a 40-0 masterclass versus Prairie View A&M on Sept. 14. Boston College suffered its first loss in the Bill O'Brien era, 27-21 to then-No. 6 Missouri.
6 Oregon at Oklahoma State
NCAAFThe No. 6 Ducks visit the Cowboys in Week 2 game at Boone Pickens Stadium. Oregon enters following a hard-fought win against Boise State in its opener. Oklahoma State plays its home opener under new coach Eric Morris after a road loss to Tulsa.
Bowling Green at Nebraska
NCAAFThe Bowling Green Falcons visit the Nebraska Cornhuskers in Week 2 at Memorial Stadium. Head coach Matt Rhule has Nebraska sitting at 1-0 after a 49-21 victory over Ohio in Week 1. The Falcons are seeking their first win after a tough opening loss.
Duke at Illinois
NCAAFThe Illinois Fighting Illini host the Duke Blue Devils in a non-conference Week 2 action. Illinois enters following a 42-23 victory over UAB led by Collin Dixon's two receiving scores, while visiting Duke comes off a 17-3 win over Tulane.
1 Ohio State at 4 Texas
NCAAFNo.4 Texas Longhorns host the No.1 Ohio State Buckeyes at DKR-Texas Memorial Stadium in Week 2. Home Texas counts on Arch Manning after four touchdown passes, while visiting Ohio State relies on Julian Sayin following a 320-yard, three-score opener.
16 Penn State at Temple
NCAAFNo. 16 Penn State travels to Lincoln Financial Field to face Temple. Head coach Matt Campbell takes the Nittany Lions on the road behind QB Rocco Becht, while K.C. Keeler's Owls enter at 1-0. Penn State holds a 40-4-1 lead in the all-time series.
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Wisconsin at 3 Notre Dame
NCAAFNotre Dame plays host to Wisconsin at Lambeau Field in Green Bay to open the 2026 season. The Fighting Irish look to build on their 10-2 finish from last season, while the Badgers look to bounce back from their 17-7 loss to the Golden Gophers.
Rutgers at Boston College
NCAAFThe Eagles host the Scarlet Knights at Alumni Stadium in Chestnut Hill. Rutgers enters Week 2 following a 37-21 loss to the Massachusetts Minutemen, while Boston College seeks recovery after falling 34-15 to the Cincinnati Bearcats in Week 1.
Wake Forest at Purdue
NCAAFThe Purdue Boilermakers face the Wake Forest Demon Deacons at Ross-Ade Stadium. Purdue opened its 2026 campaign with a 44-19 victory over Indiana State, while head coach Jake Dickert has Wake Forest at 1-0 following a 38-16 win over Akron.
Howard at 5 Indiana
NCAAFThe No.5 Indiana host Howard for a Week 2 matchup. Indiana builds on a 52-16 win over North Texas behind Josh Hoover's 231 passing yards, while Howard looks to bounce back from a 28-21 loss to Richmond despite 109 yards from Ja'Shawn Scroggins.
11 Oklahoma at Michigan
NCAAFSemana 2 del fútbol americano universitario de la NCAA. Oklahoma enfrenta a Michigan. Desde el Michigan Stadium.
Eastern Michigan at Michigan State
NCAAFEastern Michigan visit Michigan State in a Week 2 in-state showdown in East Lansing. The Spartans look to build momentum after a 30-20 opening victory over Toledo, while the visiting Eagles aim to rebound from a 27-21 loss to San Jose State.
Maryland at UConn
NCAAFThe UConn Huskies host the Maryland Terrapins at Pratt & Whitney Stadium in East Hartford. UConn looks to build on 56-7 win over Lafayette, while Maryland enters after a dominant 62-0 shutout against the Hampton Pirates in this regular-season game.
Utah State at 19 Washington
NCAAFThe Utah State Aggies visit No. 19 Washington Huskies at Husky Stadium. The Huskies enter Week 2 after a 24-10 win over the Cougars. Second-year coach Bronco Mendenhall leads Utah State looking to bounce back from a 29-17 loss to Idaho State.