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Eastern Illinois at Minnesota
NCAAFThe Eastern Illinois Panthers face the Minnesota Golden Gophers at Huntington Bank Stadium. The Panthers suffered a seven-game loss streak in their 2025 season, while the Golden Gophers won against the Lobos 20-17 on Dec. 26, 2025 in the Rate Bowl.
Alabama-Birmingham at Illinois
NCAAFThe UAB Blazers and the Illinois Fighting Illini battle at Gies Memorial Stadium. The Blazers won against the Golden Hurricanes, 31-24, in their final 2025 game. Illinois defeated Tennessee 30-28 in the Liberty Mutual Music City Bowl in 2025.
6 Indiana at 1 Ohio State
NCAAFThe nation's only two unbeaten programs face off in the Big Ten championship game as No. 2 Indiana plays No. 1 Ohio State for the CFP's top seed. The Buckeyes seek a record 25th outright conference crown. The Hoosiers have not won a title since 1967.
Indiana State at Purdue
NCAAFThe Sycamores host the Boilermakers in West Lafayette to open a Week 1 game. The visiting Boilermakers suffered a 56-3 loss to Indiana in their last season and hope to bounce back, while Indiana State was defeated by Murray State 31-17 in its finale.
Toledo at Michigan State
NCAAFToledo Rockets visit the Michigan State Spartans at Spartan Stadium to open the season. The home Spartans look to improve on a 4-8 finish in 2025, while the visiting Rockets targets early momentum coming off an 8-5 record last season.
Fresno State at 14 USC
NCAAFThe USC Trojans host the Fresno State Bulldogs in Los Angeles for a Week 1 game. Home USC looks to build on a 42-26 victory over the Spartans led by quarterback Jayden Maiava, while visiting Fresno State looks to build on an 18-3 last season win.
North Texas at 6 Indiana
NCAAFThe Mean Green play the Hoosiers at the Memorial Stadium in Bloomington for a Saturday Week 1 opener. Indiana looks to maintain top form after finishing No.1 in the final 2025 poll, while visiting North Texas aims to improve off a No.24 rank finish.
Ohio at Nebraska
NCAAFNebraska hosts Ohio at Memorial Stadium for a Saturday opening kickoff in Lincoln. Nebraska looks to bounce back from a 44-22 season-ending bowl loss against Utah, while visiting Ohio aims to maintain momentum off a 9-4 campaign in 2025 play.
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7 Miami at 1 Ohio State
NCAAFThe No. 10 Miami Hurricanes face the No. 2 Ohio State Buckeyes at AT&T Stadium. This is a high-stakes College Football Playoff Quarterfinal matchup. Miami advanced after a gritty 10-3 road upset over No. 7 Texas A&M in the CFP First Round.
Massachusetts at Rutgers
NCAAFThe UMass Minutemen and the Rutgers Scarlet Knights meet for a Week 1 season opener at SHI Stadium. The Minutemen suffered a 0-12 winless record during their 2025 season and look for redemption. Rutgers lost to Penn State in their final 2025 game.