
Defense attorney Perry Mason defends dozens of falsely accused people over the course of this long-running courtroom drama, and he manages to clear each and every one of them, usually by drawing out the real criminal on the witness stand. He is capably assisted by investigator Paul Drake and secretary Della Street, and is a continual thorn in the side of District Attorney Hamilton Burger.

Perry becomes involved in a murder charge when a private investigator deals in blackmail.

Perry's client, a woman who retained him on a tax matter, finds herself charged with the fatal poisoning of her husband.

Perry's client in a blackmail payoff is charged with a double murder he believes she did not commit; guest Angie Dickinson.

A juvenile, previously convicted of theft, is charged with stealing a piece of antique jewelry and killing its owner.