
After the unsolved murder of his wife, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

A relaxing getaway in wine country turns into a crime-filled weekend for Monk.

Monk searches for the truth when it appears that his late wife is alive.

Natalie asks Randy to be her date to her brother's wedding; but when he's run down in the parking lot, Monk steps in to figure out what exactly is going on.

A childhood crush asks Monk's help in solving a mysterious murder.