
After the unsolved murder of his wife, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

Monk races to find a stolen diamond and claim a million-dollar reward.

A childhood crush asks Monk's help in solving a mysterious murder.

A police officer dies after drinking a poisoned bottle of wine that was intended for Capt. Stottlemeyer.

Monk enters the world of high fashion when he believes a young man accused of a model's murder is innocent.