
After the unsolved murder of his wife, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

Monk searches for the truth when it appears that his late wife is alive.

Natalie asks Randy to be her date to her brother's wedding; but when he's run down in the parking lot, Monk steps in to figure out what exactly is going on.

A childhood crush asks Monk's help in solving a mysterious murder.

A police officer dies after drinking a poisoned bottle of wine that was intended for Capt. Stottlemeyer.