
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

Wolowitz questions his engineering skills after he and Sheldon can't get a toy drone to fly; a canceled flight puts Leonard's plans in jeopardy; Raj sets his parents against one another after he's cut off financially.

Leonard, realizing his pursuit of Penny is fruitless, has an unexpected encounter with a fellow scientist (Sara Gilbert).

When Sheldon's and Leonard's mothers finally meet, personalities collide; Howard decides to do his share of the chores -- with a little help from his friends.

Leonard must choose who to bring with him when he goes to see the Large Hadron Collider on Valentine's Day.