
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When DNA proves that a man who practically admits to a brutal attack is innocent, police wonder why he is willing to take the blame.

Insect evidence helps to solve the mystery of a woman found dead near a river bank.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.

In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.