
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.

Police suspect a gay college student's slaying is a hate crime until forensic evidence points the case in another direction.

In a wealthy area of Philadelphia, police are called to the scene of what seems like a regular accidental drowning; the investigation begins to focus on one person who has many reasons to want the victim dead.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.