
The Turtles, as teenagers, deal with their new life as heroes while also dealing with the pressures of going to high school in New York City.

With some loose Mutagen at stake, Mikey questions Rod's siblings, the notorious and eccentric Maude and Todd; they are trying to get their hands on some mutant blood; can Mikey find Rod before it's too late?

No one likes Rod, especially the Turtles; Bishop's former intern keeps trying to kidnap them and steam their mutant blood; but when Rod himself is kidnapped, Mikey is on the case; his first suspect -- the mutant-hating Mechazoid maker Bishop.

Leo's finally got his arch enemy as the Turtles take on Scratch and his mutant vampire fleas -- a grudge match fifteen years in the making; the final battle begins!

The villainous, dog-hating madman known as Scratch holds the city's dogs hostage; he demands that the Night Ninja surrender; Leo, April and the Turtles realize there's more to Scratch than meets the eye.