
The Turtles, as teenagers, deal with their new life as heroes while also dealing with the pressures of going to high school in New York City.

Mikey and Rod confront Rod's dad, uncovering who kidnapped Rod, the mystery of the mutagen and the truth behind Rod's strange family; but even with the help of his brothers, can Mikey defeat the mutant known as Muckman?

With some loose Mutagen at stake, Mikey questions Rod's siblings, the notorious and eccentric Maude and Todd; they are trying to get their hands on some mutant blood; can Mikey find Rod before it's too late?

No one likes Rod, especially the Turtles; Bishop's former intern keeps trying to kidnap them and steam their mutant blood; but when Rod himself is kidnapped, Mikey is on the case; his first suspect -- the mutant-hating Mechazoid maker Bishop.

Leo's finally got his arch enemy as the Turtles take on Scratch and his mutant vampire fleas -- a grudge match fifteen years in the making; the final battle begins!