
Not to be confused with Newhart's eponymous 1961 variety show, "The Bob Newhart Show" finds the comic playing Bob Hartley, a Chicago psychologist living with wife Emily in a highrise. Bob is forced to deal with crazy patients, his wife and their friends.

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Bob's divorced neighbor, Howard Borden, is convinced that his son, Howie (Moosie Drier), doesn't really like him. Later, Howard's ex-wife convinces him that Howie thinks he is the greatest guy in the world.
Bob wants to watch football every Monday night, but Emily says that's unfair because other activities keep the couple busy every other night of the week, leading to an all-night argument that ends only when the two participants become exhausted.
Bob and Emily have been trying for some time to have a child. When they attend a party where the conversation turns to the subject of children, they feel so left out that they decide to adopt a child.
When Bob returns from his vacation in Mexico, Jerry announces that he is about to be married to a girl he just met. Cynthia, a beautiful but domineering oral hygienist, becomes too much for Jerry, and he realizes that he has made a mistake.