Washington, D.C., Police Chief Jack Mannion, runs a modern-day "Untouchables" team to patrol the most crime-ridden, drug-infested streets in his city.

Police headquarters is quarantined when a man in custody appears to have an unknown infectious virus.

Mannion and Vanessa get carjacked while visiting Los Angeles.

Debreno is assigned to protect a popular singer (Lee Ann Womack) who has received multiple death threats.

Mannion's uncle (Ernest Borgnine) witnesses the murder of a jeweler and pushes his nephew to pursue all possible leads.