
Peter Parker is a very intelligent young man. But when Peter gets bitten by a radioactive spider during a school field trip to Oscorp, he develops spider-like powers including the ability to shoot webbing from his hands and to climb up walls. When tragedy strikes close to his home, Peter must decide how to come to terms with the momentous loss but also how he must adjust to his new job as a masked superhero. Peter will face all manner of villains and those looking to cause trouble as he attempts to rid his city of corruption.

Spider-Man faces off against his most bizarre bad guy yet, Jack O' Lantern; he turns Prowler, a reluctant villain, to the side of heroes when he helps him save his brother.

Spidey tracks the identity of the mysterious boss that put a price on his head and who has been sending villains after him.

Spider-Man and Miles Morales discover Doc Ock, whose mind has been hiding inside the metal body of the Living Brain, has been behind the mysterious bounty for Spider-Man's head.

Spider-Man must fight his way through the Super-Villain Holding Facility to challenge the Living Brain, the robot body that houses the mind of Doctor Octopus.