
Emergency room nurse Jackie Peyton does everything she can to provide her patients with the best care possible while navigating the waters of a crumbling health-care system. But she has a secret that is increasingly difficult to keep from people -- she relies on Vicodin and Adderall to get her through high-stress shifts at a New York hospital, where she isn't above bending the rules to keep things running smoothly in the face of indifferent doctors, penny-pinching bean counters and miles of bureaucratic red tape.

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Jackie has a dream about Cruz and using; Coop becomes insistent about involvement with O'Hara's child; Zoey questions her feelings for Lenny; O'Hara takes action.
Jackie covers for Cruz; Jackie's lawyer advises her to be tough; Zoey surveys her co-workers; Akalitus asks the staff to participate in an elaborate charade.
Cruz takes revenge on Jackie's coworkers; Eddie supports Jackie's case; Lenny intends to move to Europe; O'Hara leans on Coop.
Grace refuses to attend school; Jackie seizes control of the E.R.; Cruz suffers a pulmonary episode.