A women's health clinic in Philadelphia is the setting for this drama. While dealing with a number of medical issues, the show often revolves around the conflict between the clinic's directors: one a passionate advocate for patients and the other a more discipline-oriented doctor.

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The clinic may receive a generous donation if Lu agrees to perform a set of physicals; Andy competes for the vacated position of chief of surgery; Kayla treats a teen's gunshot wound.
A resident attempts suicide; Lu helps a gymnast find a liver donor for her sister. Former Olympian Kerri Strug guest stars.
Andy treats a patient who is critically injured in a fall into a ravine; a patient tests positive for avian flu; Peter treats a woman with severe allergies.
Lu helps a girl get into a state-funded mental-health facility; Andy discovers a young couple's true intentions for in vitro fertilization.