A women's health clinic in Philadelphia is the setting for this drama. While dealing with a number of medical issues, the show often revolves around the conflict between the clinic's directors: one a passionate advocate for patients and the other a more discipline-oriented doctor.

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While honeymooning in Costa Rica, Lu visits a clinic for orphaned children; Kayla believes a mother is abusing her child.
Dylan helps save the heart of a Down syndrome patient; Lu helps two teenage girls get out of gang life; Lu is pregnant.
Dylan tries to save the life of the governor; Lu is an advocate for a death row patient; Kayla seeks Dylan's help on an emotional case.
Lu helps a patient accused of welfare fraud when her children's DNA doesn't match her own.