
Thelma "Mama" Harper is the quick-tempered, blue-haired matriarch of the Harper family who lives with son Vint and his wife, Naomi, who were forced to move into Mama's basement after losing money in a business deal gone awry. After Vint's kids from a previous marriage leave the house, Mama's delinquent grandson Bubba is ordered to live with his grandmother after being released from juvenile hall and placed on probation. Iola Boylen, Thelma's friend and neighbor, is a frequent visitor to the Harper household, which is often the site of bickering between abrasive Mama and her loved ones. Vicki Lawrence stars as Mama, a character she originated in sketches on "The Carol Burnett Show."

Bubba is looking for a band for Homecoming, and succeeds in booking the Bonecrushers; after telling the family that the band will be staying with them, it turns out the Bonecrushers are an all-female heavy metal band.

Vint learns that he is going to lose his job because Kwik Keys is going out of business; when it turns out that Mama owns ten shares of Bernice, the company that owns Kwik Keys, she sets out to stop the store from closing.

After a man named Mr. Wheeler asks for $800 in good faith money for one of Vint's inventions, Mama learns that the man is a con artist and ends up working with the police to catch him.

Lola and Mama (Beverly Archer, Vicki Lawrence Schultz) become enemies when they compete in a rose show.