
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

The hospital is locked down when a newborn disappears from the nursery; new insights about the team's personal lives, relationships and regrets surface.

House and the team treat a knight from a community of men and women living according to the ideals of the High Renaissance; Wilson and an ex start over.

A woman in an open marriage suddenly becomes ill during a date with her boyfriend; House tests Wilson and Sam's relationship.

The team treats an ailing groom; House, Chase and Foreman visit a karaoke bar during a raucous night out.