
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

House agrees to stop taking painkillers for a week in exchange for a month without clinic duty, but the team thinks detox is affecting his judgment in the case of a young man's unexplained blood loss.

A severely broken arm reveals underlying problems and ends the comeback plans of a major league pitcher, whom House suspects is taking steroids.

When a financial supporter of the hospital gets a divorce, his son falls ill and begins to believe he is cursed, leaving House and the team trying to treat him and deal with his demanding father.

Billionaire entrepreneur Edward Vogler buys his way into becoming chairman of the board with plans to use the facility as a new biotech venture, which could mean the hospital no longer needs the services of Dr. House.