
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

The team discovers its teenage patient isn't just being dramatic when her symptoms worsen; House becomes consumed with determining the cause of a 4-year-old's death; Park tries to get Chase to admit why he has become obsessed with grooming.

During an interrogation at the witness stand, a prosecutor has what he thinks is a heart attack; Wilson is determined to prove that House is hiding something; Park starts to come out of her shell.

An Alzheimer's patient participating in a drug trial suffers from a violent temper; Wilson treats a patient who claims to be in a chaste marriage.

When a homeless teenager's symptoms get worse, adult consent is required for an invasive surgery; Taub tries to connect with his daughters; House threatens Foreman's relationship with a married woman.