
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

When Tom Wright, a senator with presidential aspirations, becomes ill, House examines him and finds that the symptoms point toward AIDS, a condition that would squash his career.

House and his team scramble to find the cause of kidney and brain dysfunction in a pregnant patient, leaving the woman and her husband to face a heartbreaking choice; Vogler continues his quest to have House fired.

A meningitis scare overwhelms the resources and staff of the hospital, but House singles out a 12-year-old patient whose symptoms are similar to but not quite right for the disease.

House and Cameron explore their relationship; the team tries to discover what is causing a young man to have blood clots and strokes.