
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

The team notices behavioral changes in a marriage counselor who collapsed during a speaking engagement; House and Dominika work to convince Immigration they are a happy couple; House chooses a team leader.

While House and his team treat a blind man, House's mother Blythe tells her son about her new relationship.

The team treats an Army veteran who refuses treatment unless he and his brother are given information about their dead father; Adams seeks help when she suspects House is sick.

House splits his time between treating a firefighter for uncontrollable shivering, giving Tritter a piece of his mind and handling his trial for forging prescriptions.