
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

When a homeless teenager's symptoms get worse, adult consent is required for an invasive surgery; Taub tries to connect with his daughters; House threatens Foreman's relationship with a married woman.

Dr. Walter Cofield, Foreman's former mentor, places House and the team under review after a violent incident involving a patient.

As Chase treats Moira, a cloistered nun who is on the verge of making life-altering vows, they form a connection that causes Moira to question her faith; Taub and House take part in a series of pranks.

The team notices behavioral changes in a marriage counselor who collapsed during a speaking engagement; House and Dominika work to convince Immigration they are a happy couple; House chooses a team leader.