
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

While treating a drug addicted patient, House is forced to look at his own life, future and personal demons.

Looking back at the series so far, including interviews with stars and producers.

Dr. House and his team try to save the life of a kindergarten teacher who began speaking gibberish and passed out in front of her students.

Dr. House and the team think a teenage lacrosse player has multiple sclerosis until the boy's night-terrors disprove their diagnosis.