
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

Dr. House shows special interest in a schizophrenic with deep-vein thrombosis and her teenage son, who is her primary caregiver.

When a young housewife falls ill, House suspects that she has contracted a rare sexually transmitted disease, but she and her husband, Dominic Purcell, each deny having an affair.

House and his team investigate the mysterious poisoning of a high-school student, and they think they have the answers they need until a second teen develops the same symptoms.

A jazz musician checks into the hospital, believing he is dying of ALS and signs a "do not resuscitate" order; House disagrees with the diagnosis and violates the order to save the man's life, landing himself in court.