
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

House and Cameron explore their relationship; the team tries to discover what is causing a young man to have blood clots and strokes.

A woman from Dr. House's past returns to the hospital, where she used to be legal counsel, seeking his help in diagnosing the illness her husband has.

While House works to save Stacy's husband, he cannot help but think his feelings for her may have reignited.

When death row inmate Clarence mysteriously collapses after hallucinating, House jumps at the case for its difficulty and because he thinks it is "cool."