
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

A 16-year-old patient has internal bleeding, but his Gypsy parents arrive and refuse all modern medical treatment.

A snowstorm leaves the ER short-staffed on Valentine's Day; House determines that Foreman's patient, who was injured in a car accident, has a rare condition that makes her completely insensitive to pain.

A 35-year-old musical savant is admitted to the hospital with a rare movement disorder; Cameron discovers that House has been in contact with a Massachusetts hospital.

House's newest patient, an ex-Marine who had saved House's life in a dream the night before, intrigues him.