
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

After a fight on the ice, a 22-year-old minor league hockey player collapses and coughs up blood; House stuns Wilson; Chase has an offer for Park.

House and the team treat a man who sheds tears of blood; when House acts out when his favorite prostitute decides to leave the business.

The team treats a boy who wakes up from nightmares of being choked still unable to breathe; Park has intimate dreams about co-workers; Dominika discovers a secret that has the potential to ruin her relationship with House.

When the team treats a 6-year-old with multiple health issues, they must collaborate with her mother (Jessica Collins), who is also a doctor; Wilson and House go on vacation.