
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

Billionaire entrepreneur Edward Vogler buys his way into becoming chairman of the board with plans to use the facility as a new biotech venture, which could mean the hospital no longer needs the services of Dr. House.

When a mob informant suddenly collapses before court, House and his team try to cure him or determine whether he is faking.

House and his team blame an adverse reaction to diet pills after an obese 10-year-old girl has a heart attack but, ultimately, they find another cause for her illness.

When Tom Wright, a senator with presidential aspirations, becomes ill, House examines him and finds that the symptoms point toward AIDS, a condition that would squash his career.