
When delinquent Yusuke dies saving someone else, he gets a second shot at life as a spirit detective; with his former rival, Kuwabara, and demons Kurama and Hiei, Yusuke takes on the monsters and humans who desire to rule the three realms of reality.

Between the Living World and the Demon World, a tunnel is being carved that could usher in darkness and chaos; in a bold move, Sensui begins his search for the person that will finally allow him to complete the tunnel.

A mind reader, Murota, is the Spirit Detective's hope to find the truth behind the tunnel.

Yusuke's mind reader, Murota, is shot while attempting to weed out the psychic responsible for the tunnel between worlds; when the gang takes Murota to the hospital, new dangers appear.

The Doctor, a human with immense psychic powers, infects the entire hospital with a deadly virus; in order to save his friends, Yusuke may have no choice but to destroy the wretched creature.