
When delinquent Yusuke dies saving someone else, he gets a second shot at life as a spirit detective; with his former rival, Kuwabara, and demons Kurama and Hiei, Yusuke takes on the monsters and humans who desire to rule the three realms of reality.

Yusuke's mind reader, Murota, is shot while attempting to weed out the psychic responsible for the tunnel between worlds; when the gang takes Murota to the hospital, new dangers appear.

The Doctor, a human with immense psychic powers, infects the entire hospital with a deadly virus; in order to save his friends, Yusuke may have no choice but to destroy the wretched creature.

Yusuke has defeated the Doctor, one of the seven psychics trying to forge a tunnel between worlds.

Kuwabara struggles to keep up with Sea Man's power.