
Andy Taylor is the widower sheriff of the small, sleepy North Carolina town of Mayberry. Andy and son Opie live with Aunt Bee, who takes care of the family. Andy's deputy is his bumbling but neurotically hilarious cousin, Barney Fife. Among Andy's Mayberry friends is the town's resident barber, Floyd.

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Andy and Barney discover that the old Morrison sisters, Mayberry's local florists who have been helping them arrest moonshiners, are actually in the moonshining business.
Colonel Harvey, a traveling salesman, arrives at Mayberry and captivates Aunt Bee, who buys Harvey's dubious elixir and invites him for dinner. When Andy and Barney find Aunt Bee clearly drunk, they analyze Harvey's elixir.
Andy tries to help Mayberry newcomers Fred and Jennie Boone whose constant yelling and fighting is disrupting the town's peace.
Andy unexpectedly has his hands full as The Darlings, a family of musicians from the mountains, arrive in Mayberry to meet a bus due the next day.