
Andy Taylor is the widower sheriff of the small, sleepy North Carolina town of Mayberry. Andy and son Opie live with Aunt Bee, who takes care of the family. Andy's deputy is his bumbling but neurotically hilarious cousin, Barney Fife. Among Andy's Mayberry friends is the town's resident barber, Floyd.

Andy and Barney look forward to seeing their high-school sweethearts at the Mayberry Class of '45 reunion.

Colonel Harvey, a traveling salesman, arrives at Mayberry and captivates Aunt Bee, who buys Harvey's dubious elixir and invites him for dinner. When Andy and Barney find Aunt Bee clearly drunk, they analyze Harvey's elixir.

Barney and Gomer are responsible for watching over two thieves who are temporarily jailed in Mayberry. Between the two of them, the criminals manage to escape three times.

Rafe Hollister, a farmer with a golden voice, is chosen to represent Mayberry at a musical, but Mayor Stoner believes he looks too seedy. It is then up to Andy to make Rafe presentable enough.