
Andy Taylor is the widower sheriff of the small, sleepy North Carolina town of Mayberry. Andy and son Opie live with Aunt Bee, who takes care of the family. Andy's deputy is his bumbling but neurotically hilarious cousin, Barney Fife. Among Andy's Mayberry friends is the town's resident barber, Floyd.

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Colonel Harvey, a traveling salesman, arrives at Mayberry and captivates Aunt Bee, who buys Harvey's dubious elixir and invites him for dinner. When Andy and Barney find Aunt Bee clearly drunk, they analyze Harvey's elixir.
Andy unexpectedly has his hands full as The Darlings, a family of musicians from the mountains, arrive in Mayberry to meet a bus due the next day.
The Taylor family starts an exciting vacation in Hollywood, including a visit to a movie studio.
Malcolm Merriweather, an English tourist, passes by Mayberry on a bicycle; after causing a traffic accident, he agrees to work off the damages as Andy's personal valet.