
A dedicated group of forensic investigators at the Las Vegas Crime Lab works to solve often-grisly crimes in Sin City. Heading up the graveyard shift (an appropriate term in this case) is supervisor D.B. Russell, a "Left Coast" Sherlock Holmes who devours crime novels. Members of Russell's team include Julie Finlay, Nick Stokes, Sara Sidle (the team's moral compass), Greg Sanders and Morgan Brody. The investigative team works closely with Capt. Jim Brass -- a seasoned detective who is a protector of CSI -- Dr. Al Robbins -- medical examiner -- and quirky lab technician David Hodges. Previous leaders of the group include Gil Grissom and Dr. Ray Langston.

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The death of a wealthy socialite leads Grissom and his team into the world of illegal dog fighting; Warrick tries to clear his name in the murder of an exotic dancer.
Grissom and his team investigate two murders at the annual bull-riding finals -- killings that may be related to illegal bull breeding; Ty Murray, Jewel and Shooter Jennings guest star as themselves.
Grissom and the team battle the flu while investigating the deaths of several key witnesses in a grand jury case involving a dangerous Las Vegas gang.
Catherine searches for clues in the case of a murdered 3-year-old girl, found in a cardboard box behind a comedy club.