
A dedicated group of forensic investigators at the Las Vegas Crime Lab works to solve often-grisly crimes in Sin City. Heading up the graveyard shift (an appropriate term in this case) is supervisor D.B. Russell, a "Left Coast" Sherlock Holmes who devours crime novels. Members of Russell's team include Julie Finlay, Nick Stokes, Sara Sidle (the team's moral compass), Greg Sanders and Morgan Brody. The investigative team works closely with Capt. Jim Brass -- a seasoned detective who is a protector of CSI -- Dr. Al Robbins -- medical examiner -- and quirky lab technician David Hodges. Previous leaders of the group include Gil Grissom and Dr. Ray Langston.

The death of a first-class passenger on a flight to Las Vegas has Grissom and his team scrambling to examine the physical evidence and get testimony from the other passengers.

Grissom and Sara investigate a homicide in the mountains; Catherine and Warrick probe an artful theft.

Grissom and Willows hunt down the Highway I-15 serial killer; Sidle and Brown are assigned to solve a robbery/murder.

Grissom is called to help a man on death row who is trying to clear his name; Catherine and Nick investigate the execution-style murder of a teenager.