
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

Mark helps an old nemesis escape a forced retirement by Capt. Newman by investigating a murder which resembles the work of the "Clown Killer."

Mark, Jesse and Amanda are among the guests present at an elegant hotel that has been deliberately contaminated with a deadly microbe.

To investigate a possible murder, Dr. Sloan goes into a house of roommates who are monitored 24 hours a day by cameras for a national television series.

Mark gets wrapped up in the world of high fashion and designer drugs while tracking down the person responsible for planting a bomb that killed his friend on his wedding day.