
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

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Mark, Jesse and Amanda are among the guests present at an elegant hotel that has been deliberately contaminated with a deadly microbe.
Dr. Sloan's jury duty ends on a unique note when the defendant in the case is suddenly murdered after the verdict is read.
An accident involving a correctional bus brings prisoners to Community General, and a man convicted of murdering his wife takes Mark hostage.
Mark protects his kidnapper from police while trying to prove him innocent of his wife's murder, beginning a deadly chain reaction.